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Contact sensitivity to miconazole with ortho‐chloro cross‐sensitivity to other imidazoles
Author(s) -
Baes Herman
Publication year - 1991
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/j.1600-0536.1991.tb01658.x
Subject(s) - miconazole , contact dermatitis , azole , dermatology , allergic contact dermatitis , chemistry , cross reactions , patch testing , sensitivity (control systems) , medicine , allergy , immunology , antifungal , electronic engineering , antibody , engineering
A case of allergic contact dermatitis from miconazole is reported. Patch testing with a series of azole antimycotics was positive only to miconazole, isoconazole, tioconazole and oxiconazole. Those reacting are all β‐substituted 1‐phenethyl imidazoles with an ortho‐chlorine substitution on the aromatic ring. For this hitherto unreported pattern of cross‐sensitivity, the designation of “orthochloro cross‐sensitivity” is proposed.