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Capsaicin enhances allergic contact dermatitis in the guinea pig
Author(s) -
Wallengren Joanna,
Ekman Rolf,
Möller Halvor
Publication year - 1991
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/j.1600-0536.1991.tb01626.x
Subject(s) - capsaicin , medicine , sensitization , allergic contact dermatitis , guinea pig , palpation , dermatology , substance p , contact dermatitis , neuropeptide , allergy , immunology , surgery , receptor
Guinea pigs were sensitized to dinitrochlorobenzene (DNCB) by the intracutaneous route and challenged epicutaneously tin the flanks. The intensity of the allergic contact dermatitis was evaluated by inspection and palpation as well us by wet weight determination. With the purpose of diminishing tissue neuropeptides, and substance P in particular, the animals were treated with capsaicin either between induction and challenge, or before sensitization, In comparison with controls, the contact dermatitis was Enhanced in both groups of animals treated with capsaicin.