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Inhibitory effect of zinc oxide on contact allergy due to colophony
Author(s) -
Söderberg Thor A.,
Elmros Theoder,
Gref Rolf,
Hallmans Göran
Publication year - 1990
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/j.1600-0536.1990.tb05170.x
Subject(s) - patch test , zinc , abietic acid , allergy , chemistry , adhesive , contact allergy , medicine , contact dermatitis , traditional medicine , rosin , organic chemistry , resin acid , immunology , layer (electronics)
Contact allergy to a wound dressing with an adhesive mass consisting of colophony, zinc oxide and rubber (Mezinc®) was studied in 179 patients with a history of eczema. 12 patients were found to be allergic to colophony, whereas only 4 of these patients also showed a positive patch test reaction to the wound dressing. 14 patients with verified moderate contact allergy to colophony were patch tested with adhesive mass (10%). Portuguese colophony (10%), zinc oxide (10%), purified resin acids (10%) and Portuguese colophony (10%), in combination with zinc oxide. Only 3 patients reacted to the adhesive mass, whereas all patients showed a positive patch test reaction to Portuguese colophony. A combination of zinc oxide (10%) with Portuguese colophony (10%) provoked a positive patch test reaction in only 5 of these 14 patients. An allergic reaction to abietic acid (90–95% purity) was found in 7 patients and to neoabietic acid (99 +%) in 3 patients, whereas no reactions to dehydroabietic (99 +%), isopimaric (99 +%) or levopimaric acids (98 +%) were found.