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Irritant and sensitizing potential of copper, mercury and tin salts in experimental contact stomatitis of rat oral mucosa
Author(s) -
Larsson A.,
Kinnby B.,
Könsberg R.,
Peszkowski M. J.,
Warevinge G.
Publication year - 1990
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/j.1600-0536.1990.tb04775.x
Subject(s) - chemistry , oral mucosa , copper , mercury (programming language) , infiltration (hvac) , sodium , nuclear chemistry , stomatitis , irritation , tin , dermatology , pathology , immunology , organic chemistry , medicine , computer science , programming language , physics , thermodynamics
HgCl 2 , CuSO 4 , SnCl 2 , SnCl 4 , or sodium lauryl sulphate (Sls) Were Openly applied to rat oral mucosa for 1 min, followed 6 h later by histologic examination of the tissue response. Granulocytes were the predominant inflammatory cells and no lymphocytic infiltration could be seen with any of the substances tested, irritant threshold levels were defined histologically for each of the substances. CuSO 4 , was found to be non‐irritant at all concentrations. The addition of non‐irritant concentrations of SLS lowered the threshold levels for HgCl 2 and SnCl 2 , but CuSO 4 /SLS was non‐irritant at all concentrations tested. Preapplication to the mucosa of SLS at non‐irritant concentrations gave results with HgCl 2 , SnCl 2 and CuSO 4 similar to those with SLS added to the metal salt solutions. Lesions of allergic contact type could not be induced in the Oral mucosa to any of the metal salt preparations.