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Disodium cromoglycate versus diet in the treatment and prevention of nickel‐positive pompholyx
Author(s) -
Pigatto P. D.,
Gibelli E.,
Fumagalli M.,
Bigardi A.,
Morelli M.,
Altomare G. F.
Publication year - 1990
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/j.1600-0536.1990.tb01501.x
Subject(s) - disodium cromoglycate , nickel allergy , medicine , dermatology , nickel , allergy , contact allergy , gastroenterology , contact dermatitis , asthma , immunology , chemistry , organic chemistry
In some cases that have been diagnosed as contact allergy to nickel, there are repeated cutaneous eruptions of pompholyx, even in areas with no direct contact with the metal. The possible alimentary origin of dyshidrotic eczema should be considered when deciding on therapy. We have collected the clinical data for 24 patients with dyshidrotic eczema caused by nickel, to evaluate the benefit of a low‐nickel diet versus treatment with oral disodium cromoglycate, comparing both objective and subjective symptoms. A low‐nickel diet does not improve these patients but those treated with DSCG reacted better, from both objective and subjective point of view, than either the controls or the patients treated by diet. We next did intestinal permeability tests before therapy and after 15 days of treatment. We found that nickel uptake diminishes simultaneously with the reduction of absorption through the smaller aqueous “pores”. This phenomenon was greatest alter DSCG. We suggest that DSCG can help selected cases of pompholyx.