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Contact allergy to Bronopol
Author(s) -
Frosch P. J.,
White I. R.,
Rycroft R. J. G.,
Lahti A.,
Burrows D.,
Camarasa J. G.,
Ducombs G.,
Wilkinson J. D.
Publication year - 1990
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/j.1600-0536.1990.tb01500.x
Subject(s) - contact allergy , allergy , allergic contact dermatitis , medicine , dermatology , contact dermatitis , immunopathology , immunology
A total of 8149 patients were patch tested with the preservative Bronopol in 7 European contact clinics. The Majority of patients (6507) were investigated in London. Reactivity was low, with a total of 10 irritant (0.12%) and 38 allergic reactions (0.47%). In only 17 cases (0.21%) was the patch test reaction to Bronopol considered to be of current or past clinical relevance. Concomitant sensitization to formaldehyde was present in about 1/3 of patients. Based on these figures, the present sensitization rate to Bronopol in Europe seems to be quite low, which may be related to its less frequent use as a preservative in cosmetics and medicaments in comparison to parabens or isothiazolinones.