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Allergic contact dermatitis potential of 3 pyridostigmine bromide transdermal drug delivery formulations
Author(s) -
Harris Gene L.,
Maibach Howard I.
Publication year - 1989
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/j.1600-0536.1989.tb04734.x
Subject(s) - transdermal , pulmonary surfactant , pyridostigmine bromide , chemistry , contact dermatitis , allergic contact dermatitis , adjuvant , pharmacology , chromatography , sensitization , pyridostigmine , allergy , medicine , myasthenia gravis , immunology , biochemistry
Pyridostigmine bromide (PB) delivered transdermally may be a useful pretreatment for organophosphate poisoning. PB transdermal formulations were developed since this route has the potential to provide a more constant, prolonged and therapeutically‐effective drug level in the body. Guinea pig skin sensitization studies, using a variation of the split adjuvant technique, were conducted with various PB transdermal formulations as part of a safety evaluation profile, 3 gel matrix formulations were tested. The 3 formulations contained 50% PB, 30% PB with 0.198% sodium lauryl sulfate (SLS) and 30% PB with 0.21% of a proprietary surfactant (PS), respectively. SLS and the proprietary surfactant were added to the formulations as dermal penetration enhancers 9 groups of 10 animals were induced and challenged with 1 of the 3 PB or PB/surfactant formulations (3 groups per formulation). In addition, 2 groups of 10 animals were included in the study as positive controls that were induced and challenged with 2,4‐dinitrochlorobenzene (DNCB) 44% of the animals responded positively at challenge to 50% PB 80% of the animals responded positively at challenge to 30% PB/ 0.198% SLS and 82% of the animals had positive responses at challenge to 30% PB/0.21% PS. This study demonstrates that PB is a potential contact sensitizer that shows a potentiated response in the presence of surfactants.