Premium
Different skin irritation abilities of different qualities of sodium lauryl sulphate
Author(s) -
Agner Tove,
Serup Jørgen,
Handlos Vagn,
Batsberg Walther
Publication year - 1989
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/j.1600-0536.1989.tb04733.x
Subject(s) - transepidermal water loss , irritation , skin irritation , chromatography , dermatology , significant difference , chemistry , patch testing , high performance liquid chromatography , sodium , contact dermatitis , medicine , allergy , pathology , organic chemistry , stratum corneum , immunology
A marked variation in the concentration of sodium lauryl sulphate (SLS) used for irritant patch testing is found in the literature, but is hitherto unexplained. In the present study, 2 different qualities of SLS were tested clinically on healthy volunteers. The skin responses were evaluated by visual scoring as well as by non‐invasive measurement of transepidermal water loss (TEWL). blood flow and oedema. A significant difference in the skin response lo the 2 qualities was found both clinically and by non‐invasive methods used for quantitation. 5 different qualities of SLS were investigated by high‐performance liquid chromatography (HPLC). Marked discrepancies in the quantity of C 12 carbon chains in the products were found, offering an explanation for the proven difference in the clinical response. It is concluded that only SLS qualities of high purity should be used for irritant patch testing, and that both the quality and the purity of SLS should be slated.