Premium
Percutaneous absorption of 3 organic solvents in the guinea pig (III). Effect of barrier creams
Author(s) -
Boman Anders,
Mellström Gunh
Publication year - 1989
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/j.1600-0536.1989.tb04725.x
Subject(s) - skin barrier , absorption (acoustics) , chemistry , guinea pig , dermatology , chromatography , medicine , materials science , composite material , endocrinology
The efficacy of 4 barrier preparations presented as cream or foam against percutaneous absorption of organic solvents was investigated in the guinea pig. An ordinary hand cream, was also tested. Slight reduction in blood concentration of the solvents was seen when normal skin treated with barrier creams was exposed. Absorption of butanol through stripped skin treated with barrier creams was higher than absorption through skin not so treated. Barrier creams can he considered to give poor skin protection against the organic solvents investigated.