Premium
Percutaneous absorption of 3 organic solvents in the guinea pig
Author(s) -
Boman Anders,
Wahlberg Jan E.
Publication year - 1989
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/j.1600-0536.1989.tb04682.x
Subject(s) - stratum corneum , transepidermal water loss , absorption (acoustics) , chemistry , toluene , toluene diisocyanate , allergic contact dermatitis , contact dermatitis , butanol , solubility , irritant contact dermatitis , guinea pig , irritation , chromatography , ethanol , dermatology , medicine , organic chemistry , allergy , materials science , immunology , pathology , polyurethane , composite material
The influence of injuries on the percutaneous absorption of 3 organic solvent's (butanol, toluene, 1,1,1‐trichloroethane) was studied in the guinea pig. Acute (stripping, sandpaper abrasion, needle abrasion, delipidization) and subacute (irritant and allergic contact dermatitis) injuries were induced by physical or chemical treatment of the skin. Absorption of solvents was quantified by blood analysis. Induction of acute injuries markedly altered the absorption pattern of the solvents and correlated to their water solubility, Absorption of toluene and trichloroethane was reduced and that of butanol was increased compared to normal untreated skin Subacute injures had a less pronounced effect. Irritant and allergic contact dermatitis reduced the absorption of toluene and trichloroethane, and no effect was seen for butanol. For hydrophobic solvents, it is concluded that in acute injuries strata other than stratum corneum hold the barrier properties.