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Penetration of the fragrance compounds, cinnamaldehyde and cinnamyl alcohol, through human skin in vitro
Author(s) -
Weibel Helle,
Hansen Jens
Publication year - 1989
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/j.1600-0536.1989.tb04651.x
Subject(s) - cinnamaldehyde , cinnamyl alcohol , cinnamic acid , penetration (warfare) , chemistry , human skin , alcohol , in vitro , organic chemistry , biochemistry , biology , operations research , engineering , genetics , catalysis
The delivery of cinnamaldehyde and cinnamyl alcohol in fragrance through human skin has been investigated by in vitro penetration studies using full thickness human skin. Cinnamaldehyde was transformed to cinnamyl alcohol and cinnamic acid in the skin. The transformation took place in model protein solution, bovine serum albumin, as well as in skin homogenates. After conjugation of cinnamaldehyde with the protein, a lag time was observed after which cinnamyl alcohol and cinnamic acid were released. On the other hand, cinnamyl alcohol was not transformed in detectable amounts to either cinnamaldehyde or cinnamic acid during penetration of the skin.