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Tiaprofenic acid induced photosensitivity
Author(s) -
Neumann R. A.,
Knobler R. M.,
Lindemayr H.
Publication year - 1989
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/j.1600-0536.1989.tb03144.x
Subject(s) - phototoxicity , photosensitivity , dermatology , medicine , irradiation , photochemistry , chemistry , optics , biochemistry , physics , nuclear physics , in vitro
45 patients (34 patients with PLE, 11 with phototoxic or photoallergic dermatitis) were photopatch tested to tiaprofenic acid. In 23 patients (51%), phototoxic reactions were found. Positive reactions appeared within 0.5 to 48 h of irradiation. Although each patient was irradiated with 2 different UVA light sources, with significantly different energy outputs (10 J/cm 2 against 72 J/cm 2 ), the intensity and duration of positive reactions was virtually the same. We found a considerably higher rate of positive reactions than other investigators, independent of the light energy delivered. None of the patients gave a history of previous tiaprofenic acid exposure.