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Patch testing with nickel chloride in a hydrogel
Author(s) -
Fullerton Ann,
Menne Torkil,
Hoelgaard Annie
Publication year - 1989
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/j.1600-0536.1989.tb03089.x
Subject(s) - patch test , patch testing , nickel allergy , nickel , contact allergy , contact dermatitis , dermatology , chemistry , allergy , chloride , allergic contact dermatitis , medicine , immunology , organic chemistry
Various concentrations of NiCl. in a hydrogel were evaluated as a possible alternative to the standard patch test material of 5% NiSO 4 pet. Patch test responses were recorded on a total of 430 patients with known or suspected contact allergy. A Nicl2 concentration of 1% or less in the hydrogel failed to elicit a response in some patients who reacted to 5% NiSOi2 pet. The 2% NiCl 2 hydrogel produced a small increase in response frequency and may reduce false‐negative reactions. Along with the ability of the material to improve the topical bioavaitability of nickel ions, more irritant reactions were observed. However, in cases with a positive history and a negative patch test with petrolatum, the hydrogel prepared from Methocel seems to be a useful alternative vehicle for water‐soluble allergens.