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Zinc effects on nickel dermatitis in the guinea pig *
Author(s) -
Warner Ronald D.,
Dorn C. Richard,
Blakeslee James R.,
Gerken Diane F.,
Gordon John C.,
Angrick Elisabeth J.
Publication year - 1988
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/j.1600-0536.1988.tb05505.x
Subject(s) - distilled water , zinc , chemistry , contact dermatitis , allergic contact dermatitis , guinea pig , positive control , patch test , allergen , stimulation , negative control , immunology , medicine , pharmacology , allergy , traditional medicine , chromatography , organic chemistry
Prevention of NiSO 4 induced allergic, contact dermatitis (ACD) using ZnSO 4 in drinking water was studied in a guinca pig model Without ZnSO 4 intervention, nickel (Ni)‐exposure resulted in significantly higher ( p <0.05) stimulation indices (SIs) as compared to non‐exposed controls, using NiSO 4 as an allergen in the lymphocyte transformation test (LTT). Oral intake of ZnSO 4 at both 250 μg/ml double‐distilled deionized water (DDD) and 500 μg/ml DDD resulted in lower SIs than those of control guinea pigs drinking only DDD: the 250 μg ZnSO 4 /ml group had significantly lower Sis than ( p = 0.025) than controls. There was no significant correlation between intradermal test responses and the SI values of individual guinea pigs exposed to NiSo 4 Mean Zinc (Zn) concentrations in skin and in whole blood were not statistically different between the NiSO 4 exposed control and Zn supplemented groups, nor between Ni‐sensitive and non‐sensitive animals within groups. The rôle of Zn homeostasis role of the Langerhans cell, effect of Zn supplementation on Ni ACD in other species, and possible blocking effects of other metals should be investigated in future studies.