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Evaluation of the sensitising potential of 4 polyamines present in technical triethylenetetramine using 2 animal species
Author(s) -
Maisey Joanne,
Purchase R.,
Robbins M. C.,
Miller Klara
Publication year - 1988
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/j.1600-0536.1988.tb04498.x
Subject(s) - triethylenetetramine , ethylenediamine , guinea pig , chemistry , pharmacology , toxicology , medicine , biology , organic chemistry
Contact sensitivity to 4 polyamines present in technical grade triethylenetetramine was investigated using the ‘VAA mouse’ assay and the guinea pig maximization lest (GPMT). The criteria used 10 assess sensitivity in the GPMT classed all substances as having the same degree of sensitising potential The mouse assay ranked N‐(2‐piperzin‐l ylethyl)ethylenediamine as having a significantly greater sensitising potential than the other compounds.