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Objective measurement of surfactant irritation by fiber optic spectroscopy
Author(s) -
Crowe Daniel M.,
Willard Marcia S.,
Murahata Richard I.,
Aust Louise B.,
Gacula Maximo C.
Publication year - 1988
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/j.1600-0536.1988.tb02893.x
Subject(s) - irritation , skin irritation , pulmonary surfactant , erythema , biomedical engineering , chromatography , materials science , medicine , optics , chemistry , dermatology , physics , biochemistry , immunology
Erythema caused by occlusion of 3 concentrations of surfactant was quantified in vivo using a modified spectrophotometer. Standard chamber irritation test sites were evaluated objectively using the spectrophotometer and subjectively by trained observers. There was a good relationship between the instrumental and visual evaluations. The spectrum was analyzed and a region was chosen to optimize the sensitivity of the method.