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Contact allergy to imidazole antimycotics
Author(s) -
Raulin Christian,
Frosch Peter J.
Publication year - 1988
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/j.1600-0536.1988.tb02743.x
Subject(s) - clotrimazole , miconazole , econazole , active ingredient , allergy , dermatology , ethanol , contact allergy , ketone , contact dermatitis , medicine , chemistry , pharmacology , organic chemistry , immunology , antifungal
Between 1977 and 1986, 9 pateints with contact allergy to the active ingredient of imidazole cotics were found at the Department of Dermatology, University of fHeidelberg. The number of positive reaction decreased in the following order: miconazole (6), clotrimazole (3), econazole (3), isoconazole (3), and oxiconazole (1). When 5 patients were tested with a series of imidazoles in different concentratioins and vehicles (petrolatum, ethyl methyl ketone, ethanol), etrolatum turned out to be the least effective one. The active ingredient at 1% in ethanol seems to be the most suitable to miconazole or clotrimazole, since no cross reactivity was observed.