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Human cutaneous irritation: induced hyporeactivity
Author(s) -
Lammintausta K.,
Maibahi H. I.,
Wilson D.
Publication year - 1987
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/j.1600-0536.1987.tb02712.x
Subject(s) - transepidermal water loss , stratum corneum , patch test , laser doppler velocimetry , irritation , dermatology , subclinical infection , contact dermatitis , patch testing , sensitive skin , reactivity (psychology) , medicine , chemistry , allergy , pathology , immunology , blood flow , alternative medicine
The variation in human skin response to sodium lauryl sulfate (SLS) was determined, with patch and open applications. Reactions in different subjects and in multiple simultaneous patch tests were compared. Skin responses were assessed with visual scoring (VS), laser Doppler velocimetry (LDV) and transepidermal water loss (TEWL). Previous open, unpatched SLS exposure decreased patch lest reactivity to 1% SLS assessed with VS ( p <0.05) or LDV ( p <0.05). Corresponding TEWL alteration was inconstant. Variation in reactivity at different test sites in multiple simultaneous tests was considerable, though less than the variation at different test times ( p <0.05). Inter‐subject variation in test reactivity was greater than the variation between different test times or adjacent test sites. Repeated open applications and the subclinical dermatitis appear to have produced a hyporeactive state. The results suggest that non‐specific skin inflammation is elicited by multiple factors, e.g., stratum corneum integrity and vascular reactivity. Their balance determines the ensuing reactions. The induced hyporeactivity may be one of many causes of false negative diagnostic patch tests.