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Oral challenge with food additives
Author(s) -
Veien Niels K.,
Mattel Thais,
Justrsen Ole,
Nørholm Asger
Publication year - 1987
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/j.1600-0536.1987.tb02669.x
Subject(s) - placebo , food additive , preservative , food preservatives , food science , medicine , food hypersensitivity , food allergy , allergy , chemistry , pathology , immunology , alternative medicine
A randomized, placebo‐controlled oral challenge with food additives (preservatives and food colorings) was carried out in 101 patients with eczema of undetermined origin who suspected that the intake of certain foods aggravated their dermatitis. 37 reacted to I or more of the food additives but not to a placebo, while 16 reacted to the placebo, or both the placebo and food additives. 48 had no reactions. The difference between the number of reactions to the food additives and the number of reactions to the placebo was not statistically significant. The reactions could he reproduced in only 1/3 of those challenged twice. It was not possible lo correlate the reactions to the food additives in reactivity to specific foodstuffs containing the same additives. If intolerance to food additives is suspected, an diminution diet seems warranted, regardless of whether the patient reacts to oral challenge with food additives.