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Piroxicam‐induced photosensitivity
Author(s) -
Figueiredo Américo,
Fontes C. A.,
Gonçalo S.,
Caladeira M. M.,
PoiaresBaptista A.,
Teixeira F.
Publication year - 1987
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/j.1600-0536.1987.tb02664.x
Subject(s) - piroxicam , phototoxicity , medicine , dermatology , provocation test , photosensitivity , bacillus subtilis , pharmacology , chemistry , pathology , in vitro , biochemistry , alternative medicine , biology , bacteria , genetics , physics , quantum mechanics
During the last 3 years, 9 patients with a photosensitive eruption related to piroxicam therapy were seen. In all but one, it occurred within 4 days of first exposure to the drug. 7 patients required systemic corticosteroids, and 2 hospitalization, Clinical, histological and provocation studies were not conclusive in classifying the eruption as photoallergic or phototoxic. Experimental studies including photohaemolysis, Bacillus subtilis culture and nuclear magnetic resonance showed: (i) in irradiatd piroxicam solutions, there was more haemolysis; (ii) in irradiated Petri dishes, piroxicam solutions showed greater inhibition of growth of B. subtilis; (iii) Piroxicam's NMR spectrum is not modified after irradiation. The results provide evidence of piroxicam phototoxic potential.