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Safety evaluation of a barrier cream
Author(s) -
Gupta B. N,
Shanklr Ravi,
Viswanathan P. N.,
Mathur A. K.,
Shukla Lalji,
Singh Abhimanyu
Publication year - 1987
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/j.1600-0536.1987.tb02635.x
Subject(s) - stratum corneum , thickening , erythema , irritation , skin barrier , dermatology , guinea pig , medicine , human skin , patch testing , skin irritation , allergy , contact dermatitis , chemistry , pathology , immunology , biology , polymer science , genetics
A barrier cream containing propylene glycol, silica, xylene, dioctyl and was applied topically for 3 months in 3 species of animal. Patch tests were carried out in human volunteers up to 72 h. The cream produced slight erythema in rats, guinea pigs and rabbits, but the irritation indices remained within safe limits. Histologically, mild focal thickening and moderate thickening of stratum corneum were observed in rats and guinea pigs, respectively, after 3 mouths of daily application. Patch testing in human volunteers indicated that the barrier cream is reasonably safe for human use.