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UVB serum factor: suppression of allergic contact dermatitis in guinea pigs
Author(s) -
Christensen Ole B.,
Christensen Monica B.,
Wall Leon M.
Publication year - 1987
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/j.1600-0536.1987.tb01426.x
Subject(s) - immunosuppression , sensitization , medicine , allergic contact dermatitis , immunology , guinea pig , contact dermatitis , spleen , dermatology , allergy
Serum from guinea pigs exposed to a single high dose of UVB and from controls was injected into the spleen of normal animals 5 days prior to sensitization. When 1.0 ml was transferred 4.5 h after irradiation, immunosuppression was obtained. Transfer of 1.5 ml of serum 2.5 h after irradiation failed to induce immunosuppression. This experimental model in guinea pigs might be valuable in further studies investigating the effect of other modalities of ultraviolet exposure (e.g., PUVA or high‐dose UVA) on the release of soluble serum factor(s) inducing immunosuppression in allergic contact dermatitis.