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Contact allergy to an epoxy reactive diluent: 1,4‐butanediol diglycidyl ether
Author(s) -
Jolanki Riitta,
Estlander Tuula,
Kanerva Lasse
Publication year - 1987
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/j.1600-0536.1987.tb01385.x
Subject(s) - epoxy , diglycidyl ether , diluent , epoxide , glue , chemistry , contact allergy , polymer chemistry , bisphenol a , materials science , composite material , contact dermatitis , organic chemistry , allergy , medicine , catalysis , immunology
3 female workers in a brush factory developed contact allergy from a 2‐component epoxy glue containing epoxy resin (37% w/w), reactive diluents: i.e., l,4‐butanediol diglycidyl ether (BDDGE) 3%, glycidyl ethers of aliphatic alcohols (Epoxide 8) 0.03% and phenyl glycidyl ether (PGE) 0.01%: and inert fillers. All 3 patients were positive to the resin component of the glue and to BDDGE, indicating that BDDGE was the main allergen. 2 of the patients reacted to PGE, but none to the 3rd reactive diluent (Epoxide 8) in the glue. 2 of the patients did not react to epoxy resin, indicating that BDDGE may be an even stronger sensitizer in humans than epoxy resin, and that it does not cross‐react with epoxy resins. Permeation studies revealed that BDDGE penetrates disposable PVC and rubber gloves in less than 30 min; thus, contaminated gloves should be replaced immediately. Reactive diluents should be included in patch test series if contact allergy to epoxy products is suspected.