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The sensitizing capacity of coumarins (II)
Author(s) -
Hausen B.M.,
Kallweit M.
Publication year - 1986
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/j.1600-0536.1986.tb01370.x
Subject(s) - dermatology , medicine , chemistry
5 coumarins used in perfumery, cosmetics, therapeutic ointments or occurring naturally were investigated by Freund's complete adjuvant technique (FCAT) in guinea pigs to determine their contact sensitizing potency. 4‐Methylesculetin was also studied. Esculetin. dihydrocoumarin and daphnetin were found to be moderate to strong sensitizers, while fraxetin was nearly and 7‐methylcoumarin completely inactive. The results corroborate the hypothetical view that only those coumarins having a catecholic disubstitution in the benzene ring, e.g., esculetin. 4‐methylesculetin. daphnetin, can become sensitizers on the basis that they are capable of forming ortho‐quinones under oxidizing conditions.