Rôle of a metabolite in allergenicity of Sudan I | Zendy

Kato Shinobu | Zendy; Itagaki Hiroshi | Zendy; Uchiyama Mariko | Zendy; Kobayashi Toshiaki | Zendy; Fujiyama Yoshio | Zendy

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Rôle of a metabolite in allergenicity of Sudan I

Author(s) -

Kato Shinobu,

Itagaki Hiroshi,

Uchiyama Mariko,

Kobayashi Toshiaki,

Fujiyama Yoshio

Publication year - 1986

Publication title -

contact dermatitis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.524

H-Index - 96

eISSN - 1600-0536

pISSN - 0105-1873

DOI - 10.1111/j.1600-0536.1986.tb01337.x

Subject(s) - metabolite , chemistry , hydroxylation , guinea pig , gas chromatography , incubation , chromatography , stereochemistry , biochemistry , biology , enzyme , endocrinology

A metabolite of Sudan I (l‐phenylazo‐2—naphthol) was isolated alter in vitro incubation with the supernatant of guinea pig liver homogenate (S·9). The metabolite was found to be 4′‐hydroxy‐l‐phenylazo‐2—naplithol by gas chromatography‐mass spectrormetry (GC‐MS), and proton and carbon‐13 nuclear magnetic resonance (NMR) analyses. It elicited positive reactions in guinea pigs sensitized ot Sudan I. It was also shown to be allergenic. The results suggest that para ‐hydroxylation of the phenyl group of Sudan I may play an important rôle in its allergenicity.

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