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Assessment of the ability of mice fed on vitamin A supplemented diet to respond to a variety of potential contact sensitizers
Author(s) -
Miller J Majsey
Publication year - 1986
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/j.1600-0536.1986.tb01255.x
Subject(s) - vitamin , contact dermatitis , medicine , immunology , physiology , food science , allergy , chemistry
The contact sensitizing potential of various compounds was tested in mice maintained on a did supplemented with vitamin A acetate. Substances, were applied epicutaneously. After challenge. increases, in ear thickness were measured and the differences in response between control and treated groups determined by the Mann Whitney lest. A number test sensilizers. including Dowicil® 200, einnamaldehyde, hydroxycitronellal and Kathon® CG gave positive sensitivity responses.