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A 6‐month dermal toxicity test with dithranol and butantrone in miniature swine
Author(s) -
Männistö P. T.,
Hashuärvi Hannu,
Kosma VeliMatti,
Collan Yrjö
Publication year - 1986
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/j.1600-0536.1986.tb01253.x
Subject(s) - dithranol , irritation , parakeratosis , dermatology , acanthosis , medicine , psoriasis , toxicity , skin irritation , irritant contact dermatitis , erythema , contact dermatitis , hyperkeratosis , allergy , immunology
Continuous topical administration of dithranol and butantrone for 6 months caused different irritation profiles in miniature swim. In paraffin wax sticks in while petrolatum, bulantrune gave rise to much less initial irritation than dithranol. but alter 2 3 weeks the situation had equalized. In gel formulations, butantrone was initially more irritant than dithranol. The vehicles themselves induced significant irritation, Signs of skin hyperplasia (parakeratosis and acanthosis) and inflammation were frequent histopathological finding at the end of the study. but no malignant changes were found. Ditlranol and butantronc did not produce any chemical hematological or serious histological abnonmalities during list treatment, suggesting a lack of systemic toxicity. No evidence of systemic absorption was Found. This long‐term study did not predict delayed irritation of butantrone observed in about % of the psoriatic patients after treatment for 1–2 months.