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Unusual contact allergens from plants in the family Hydrophyllaceae
Author(s) -
Reynolds Gary W.,
Epstein William L.,
Rodriguez Eloy
Publication year - 1986
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/j.1600-0536.1986.tb01150.x
Subject(s) - hydroquinone , prenylation , chemistry , botany , biology , organic chemistry , enzyme
The dermatitic constituents of the glandular hairs of plants in the family Hydrophyllaceae comprise a class of uncommon natural products called “phacelioids”. The chemical structures consist of various elaborations of hydroquinone attached to a C 10 to C 20 prenyl chain. Certain of these compounds are equivalent to the urushiols of Toxicadendron (Rhus) in their capacity to sensitize humans. Although structurally related to the urushiols, the phacelioids do not appear to cross‐react in humans either with urushiol, or between phacelioids with different prenyl chains.