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The phototoxic and allergenic potential of EDS liquids
Author(s) -
McKee Richard H.,
Maibach Howard J.
Publication year - 1985
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/j.1600-0536.1985.tb02508.x
Subject(s) - boiling , phototoxicity , distillation , chemistry , coal , liquefaction , organic chemistry , biochemistry , in vitro
Liquid fuels derived by direct coal liquefaction may be similar in boiling range and chemical Composition to final tar products. In the past, phototoxicity. an occupational skin disorder, has been associated with coal distillation. Consequently, the phototoxic properties of 5 materials representing the full boiling range of liquids derived from the EDS process were characterized utilizing a guinea pig model. Results with low boiling, coal derived liquids (< 200°C) were not different from unirradiated controls; however. liquids boiling above 200°C induced phototoxic effects. These results suggest that high boiling EDS liquids may possess phototoxic potential Differences in the phototoxic activities of liquids of similar boiling range may be related to chemical composition. A study of the allergenic potential of the EDS liquids described above was conducted utilizing the guinea pig maximization test. None of the lest materials produced positive responses, suggesting that EDS liquids are; low in allergenic potential.