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Chelating effect of EDTA on nickel
Author(s) -
Ketel W. G.,
Bruynzeel D. P.
Publication year - 1984
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/j.1600-0536.1984.tb01016.x
Subject(s) - chelation , ethylenediamine , nickel , edetic acid , chemistry , nuclear chemistry , medicine , inorganic chemistry , biochemistry , organic chemistry
The chelating effect of disodium ethylenediamine tetra‐acetate (EDTA) in nickel‐allergic patients was investigated. After pretreatment of the right half of the patient's back with 10% EDTA in a cream, and the left half of the back with the cream base only, various concentrations of nickel sulphate were patch tested on these areas. The blocking effect of the 10% EDTA cream appeared to be significant in comparison with that of the cream base only ( p < 0.01). A barrier cream with 10% EDTA might be of help in nickel‐allergic patients with eczema of the hands.