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The sensitizing capacity of multifunctional acrylates in the guinea pig
Author(s) -
Björkner Bert
Publication year - 1984
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/j.1600-0536.1984.tb00990.x
Subject(s) - tmpta , acrylate , pentaerythritol , ethylene glycol , polymer chemistry , methacrylate , photoinitiator , monomer , acrylate polymer , trimethylolpropane , materials science , acrylic resin , polyvinyl alcohol , chemistry , organic chemistry , polyurethane , polymer , coating , fire retardant
The multifunctional acrylates used in ultraviolet (UV) curable resins act as cross‐linkers and “diluents”. They are usually based on di(meth)acrylate esters of dialcohols or tri‐and tetra‐acrylate esters of polyalcohols. In UV‐curable coatings, the most commonly used are pentaerythritol triacrylate(PETA), trimethylolpropane triacrylate (TMPTA) and 1,6‐hexanediol diacrylate (HDDA). In other uses, such as dental composite resin materials, the di metha crylic monomers based on n‐ethylene glycol are the most useful. The sensitizing capacity of various multifunctional acrylates and their cross‐reactivity pattern have been investigated with the guinea pig maximization test. The tests show that BUDA (1,4‐butanediol diacrylate) and HDDA are moderate to strong sensitizers and that they probably cross‐react with each other. The n‐ethylene glycol diacrylates and methacrylates tested are weak or non‐sensitizers. Tripropylene glycol diacrylate (TPGDA) is a moderate and neopentyl glycol diacrylate (NPGDA) a strong sensitizer, whereas neopentyl glycal dimetha crylate is a non‐sensitizer. The commercial PET A is a mixture of pentaerythritol tri‐and tetra‐acrylate (PETA‐3 and PETA‐4). PETA‐3 is a much stronger sensitizer than PETA‐4, Simultaneous reactions were seen between PETA‐3, PETA‐4 and TM PT A. The oligotriacrylate OTA 480 is a moderate sensitizer, but no concomitant reactions were seen with PETA‐3, PETA‐4 or TMPTA. Of the multifunctional acrylates tested, the di‐and triacrylic compounds should be regarded as potent sensitizers. The metha crylated multifunctional acrylic compounds are weak or non‐sensitizers.