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Human maximization testing of D&C Yellow no. 10 and Yellow no. 11
Author(s) -
Kita Sehchi,
Kobayashi Toshiaki,
Kutsuna Hiroshi,
Kligman Albert M.
Publication year - 1984
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/j.1600-0536.1984.tb00985.x
Subject(s) - patch testing , medicine , contact dermatitis , dermatology , immunology , allergy
By the maximization test, using 0.5% D&C Yellow no, 11 in pet, 15 of 20 human volunteers became contact sensitized. All reacted to a challenge concentration of 1000 ppm and one down to 1 ppm. The high allergenic potential of this dyestuff was confirmed. There were no cross reactions to purified samples of D&C Yellow no. 10. In contrail, 5% solutions of pure D&C Yellow no. 10 Tailed to sensitize human subjects. Cross reactions to this jubilance in persons sensitized to O&C Yellow no. 11 are due to impurities.