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Histological assessment of skin damage by irritants: its possible use in the evaluation of a ‘barrier cream’
Author(s) -
Mahmoud G.,
Lachapelle J. M.,
Neste D.
Publication year - 1984
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/j.1600-0536.1984.tb00967.x
Subject(s) - silicone , skin barrier , dermatology , medicine , chemistry , organic chemistry
The histological changes induced by topical application of selected irritants are reported. The possible application of this methodology to the evaluation of the protective value of a silicone‐containing barrier cream is discussed. Although this crude method only allows objectivity of the later stages of a toxic reaction, it gives useful information about the potential protective effect of a silicone‐containing barrier cream.