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Attempts to induce contact allergy to nickel in the mouse
Author(s) -
Möller Halvor
Publication year - 1984
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/j.1600-0536.1984.tb00337.x
Subject(s) - contact dermatitis , picryl chloride , sensitization , irritation , allergy , allergic contact dermatitis , contact allergy , dermatology , adjuvant , cyclophosphamide , medicine , immunology , nickel allergy , nickel , antigen , chemistry , surgery , chemotherapy , organic chemistry
Various attempts to sensitize mice to nickel salts are described. The antigen was applied once or repeatedly by the epicutaneous or intracutaneous route and by combinations of the two. The procedures included prior irritation of the skin, treatment with Freund's complete adjuvant, cyclophosphamide or Tetramisol®, and prior sensitization to picryl chloride. Contact allergy was achieved only by repeated epicutaneous application of a strong nickel solution over a 3‐week period. The resulting dermatitis was demonstrated by a weak but significant wet weight increase of inflamed skin.