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An attempt to isolate and identify allergens in lanolin
Author(s) -
Fregert Siegfrid,
Dahlquist Inger,
Trulsson Lena
Publication year - 1984
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/j.1600-0536.1984.tb00054.x
Subject(s) - lanolin , sterol , guinea pig , chemistry , sensitization , medicine , chromatography , immunology , biochemistry , cholesterol
One sensitizer, a sterol, has previously been reported to be present in lanolin. In this study, a related substance, a sterol, with a molecular weight of 424 has been isolated. A few sensitive subjects did not real to this substance. Lanolin probably contains several sensitizers. Sensitization to lanolin in guinea pigs seems previously to have failed. In this study, a methanol extract of a lanolin preparation contain in large amounts of sterols sensitized guinea pigs.