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Influence of detergent washing powders on minimal eliciting patch test concentrations of nickel and chromium
Author(s) -
Allenby C. F.,
Goodwin B. F. J.
Publication year - 1983
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/j.1600-0536.1983.tb04470.x
Subject(s) - nickel , chromium , patch test , allergic contact dermatitis , contact dermatitis , nickel allergy , chemistry , medicine , nuclear chemistry , materials science , metallurgy , chromatography , immunology , allergy
Minimum eliciting levels of nickel have been estimated in 25 nickel‐sensitive subjects, and of chromium in 14 chromium‐sensitive subjects by patch tests with aqueous solutions of the respective metals. The minimum level of each metal required to provoke a patch test reaction was considerably greater than that found in fabric washing powder solutions and was in the majority of patients tested of the order of 112 ppm nickel (0.05% nickel sulphate) or 885 ppm hexavalent chromium (0.25% potassium dichromate). One nickel‐sensitive subject and one chromium‐sensitive subject reacted to 1 ppm of the respective metal. Fabric washing powder did not significantly alter the patch test reaction to nickel sulphate or provoke reactions in nickel‐or chromium‐sensitive subjects. EDTA significantly reduced the number and severity of patch test reactions to nickel sulphate but not those to potassium dichromate or trivalent chromium.