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Experimental sensitization of guinea pigs by drugs
Author(s) -
Rantuccio F.,
Coviello C.,
Sinisi D.,
Scardiqno A.,
Conte A.
Publication year - 1983
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/j.1600-0536.1983.tb04467.x
Subject(s) - sensitization , guinea pig , skin sensitization , medicine , contact dermatitis , dermatology , pharmacology , immunology , allergy
The capacity tegobetain, pyrrolnitrin, tolcylate and chlorquinaldol to induce delayed‐type con tact sensitization was studied in guinea pigs in 2 series of tests using the method of Magnusson & Kligman and the authors’modification of the wholly intradermal Draize technique‐ Histological examination of skin biopsies obtained from the test area demonstrated that tegobetain, pyrrolnitrin and tocyclate are potential sensitizers.