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Phototoxicity from furocoumarins (psoralens) of Heracleum laciniatum in a patient with vitiligo. Action spectrum studies on bergapten, pimpinellin, angelicin and sphondin
Author(s) -
Kavli G.,
Midelfart K.,
Raa J.,
Volden G.
Publication year - 1983
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/j.1600-0536.1983.tb04429.x
Subject(s) - furocoumarins , bergapten , phototoxicity , furocoumarin , action spectrum , vitiligo , psoralen , dermatology , medicine , pharmacology , chemistry , photochemistry , dna , biochemistry , in vitro
Investigations on light reactions in a patient with vitiligo are presented. The minimal erythema dose (MED)in the UVB area was approximately 1/1 of that in persons of skin type II. The application of furocoumarins (psoralens) increased light tolerance by 1 MED at 300–310 mm. Action spectrum studies with furocoumarins from Heracleum laciniatum showed the following order of potency: bergapten, Pimpinellin, angelicin and sphondin. The efficacy was highest at 325–350nm, with maxima at 330–335 nm. Pimpinellin was recently found to be phototoxic, but an action spectrum of sphondin is reported for the first time.