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In vivo and in vitro phototoxicity of different parts of Heracleum Laciniatum
Author(s) -
Kavli G.,
Volden G.,
Midelfart K.,
Krokan H.,
Prytz J. O.,
Haugsbø S.
Publication year - 1983
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/j.1600-0536.1983.tb04388.x
Subject(s) - phototoxicity , photosensitivity , in vivo , in vitro , chemistry , ultraviolet radiation , ultraviolet , dermatology , medicine , biology , biochemistry , materials science , radiochemistry , optoelectronics , microbiology and biotechnology
Experimental phytophotodermatitis was produced using homogenates from different parts of Heracleum laciniatum and long‐wave ultraviolet light. The homogenates of leaves and flowers produced strong phototoxic reactions, fruit slightly less. Stems were either non‐phototoxic or only slightly phototoxic. The roots or young plants did not evoke photosensitivity reactions, whereas the roots of older plants were strongly phototoxic; even roots collected from the frozen ground in December elicited strong reactions. Abdominal and midback skin were more photosensitive than skin of the lateral aspects of the underarms and legs. The in vivo findings were continued in vitro with the Candida albicans test.