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Guinea pig maximization test: Podophyllum lignans
Author(s) -
Krogh Geo,
Maibach Howard I.
Publication year - 1983
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/j.1600-0536.1983.tb04313.x
Subject(s) - podophyllum , guinea pig , traditional medicine , medicine , pharmacology , skin test , chemistry , podophyllotoxin , stereochemistry , tuberculosis , pathology
The guinea pig maximization test was used to study the sensitizing potential of Podophyllum lignans; 0.5% of each drug in propylene glycol was used for induction and 0.01%, 0.05% 0.1% and 0.5% preparations for topical challenge. The 0.1% and 0.5% preparations caused non‐allergic toxic reactions associated with the cutaneous destructive influence of these drugs; allergic responses did not occur.