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Cross‐reactivity between sesquiterpene lactones related to parthenin in parthenin‐sensitized guinea pigs
Author(s) -
Picman A. K.,
Picman J.,
Towers G. H. N.
Publication year - 1982
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/j.1600-0536.1982.tb04234.x
Subject(s) - sesquiterpene , sesquiterpene lactone , chemistry , lactone , guinea pig , allergic contact dermatitis , reactivity (psychology) , stereochemistry , allergy , biology , immunology , medicine , alternative medicine , pathology , endocrinology
The naturally‐occurring sesquiterpene lactone, parthenin, is responsible for a high incidence of allergic contact dermatitis in India. Cross‐sensitivity tests on guinea pigs sensitized to parthenin indicate a relatively high immunological specificity for this low molecular weight hapten. Coronopilin and damsin, sesquiterpene lactones most similar to parthenin, gave positive reactions but other structurally related lactones such as dihydroisoparthenin, tetra‐hydroparthenin, tetraneurin‐A, hysterin, helenalin, and tenulin, or hymenin, a diastereoisomer of parthenin, were negative.