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D & C Yellow Nos. 10 and 11: delayed contact hypersensitivity in the guinea pig
Author(s) -
Lamson Susan A.,
Kong Betty M.,
Salva Salvatore J.
Publication year - 1982
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/j.1600-0536.1982.tb04183.x
Subject(s) - guinea pig , shampoo , ethanol , sensitization , chemistry , contact dermatitis , equivalent , delayed hypersensitivity , allergy , biochemistry , medicine , immunology , organic chemistry , antigen
D & C Yellow No. 11 was found to be a skin sensitizer in guinea pigs at an elicitation concentration of 10.0% in ethanol but not at 1.0 and 3.0%. Sensitization was induced with a 50% suspension in ethanol. D & C Yellow No. 10, the disodium salt of the mono and disulfonic acids of D & C Yellow No. 11, was not a skin sensitizer nor was it capable of eliciting a response in the D & C Yellow No. 11‐sensitized guinea pigs even at a challenge concentration of 10%. Two commercial products, a soap containing 0.015% D & C Yellow No. 11 and a shampoo containing 0.002% D & C Yellow No. 10 did not elicit a reaction in the D & C Yellow No. 11‐sensitized guinea pigs.