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Disulfiram treatment of three patients with nickel dermatitis
Author(s) -
Christensen Jens Dahl
Publication year - 1982
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/j.1600-0536.1982.tb04154.x
Subject(s) - disulfiram , clearance , contact dermatitis , urine , sodium diethyldithiocarbamate , oral administration , medicine , excretion , pharmacology , dermatology , chemistry , immunology , allergy , urology , organic chemistry
Diethyldithiocarbamate chelates nickel and accelerates its excretion in the urine. Disulfiram (Antabuse®) splits into two molecules of sodium diethyldithiocarbamate after absorption. Oral administration of disulfiram tablets starting with 50 mg a day with a gradual increase in dosage to 100 mg not more than twice a day readily cleared the eczema in three patients with severe and long‐standing nickel contact dermatitis.