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Contact allergic reactions to diphenylthiourea and phenylisothiocyanate in PVC adhesive tape
Author(s) -
Fregert S.,
Trulson L.,
Zimerson E.
Publication year - 1982
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/j.1600-0536.1982.tb04132.x
Subject(s) - adhesive , thiocarbamates , natural rubber , chemistry , stabilizer (aeronautics) , organic chemistry , polymer chemistry , mechanical engineering , layer (electronics) , engineering
28 patients reacting to a PVC adhesive tape used in routine patch testing gave positive reactions to diphenylthiourea (DPTU) and to phenylisothiocyanate (PITC) in low concentrations. DPTU is a heat stabilizer in the PVC and is partly decomposed to PITC. The two substances were also found in another type of PVC. Thioureas giving isothiocyanates are also used in certain types of rubber. Isothiocyanates are present in plants, mainly of ihe Cruciferae family, and are also formed from thiuram sulfides and thiocarbamates. The connection between isothiocyanates derived from different sources should be investigated.