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The sensitizing capacity of helenin and of two of its main constituents, the sesquiterpene lactones alantolactone and isoalantolactone: a comparison of epicutaneous and intradermal sensitizing methods in different strains of guinea pig
Author(s) -
Stampf JeanLuc,
Benezra Claude,
Klecak Georg,
Geleick Horst,
Schulz KaklHeinz,
Hausen Björn
Publication year - 1982
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/j.1600-0536.1982.tb04128.x
Subject(s) - guinea pig , sesquiterpene , sesquiterpene lactone , inula , traditional medicine , chemistry , biology , stereochemistry , medicine , alternative medicine , traditional chinese medicine , pathology , endocrinology
The sensitizing capacities of helenin (an extract from a Compositae Inula helenium L.), alantolactone and isoalantolactone (two isomeric sesquiterpene lactones), were assessed by sensitizing guinea pigs of different strains: albino Himalayan spotted, Pirbright and Hartley. Both alantolactone and isoalantolactone are found to be sensitizers if injected intradermally. Only Pirbright guinea pigs showed a high sensitization rate by the open epicutaneous technique; with this method, alantolactone was the more potent sertsitizer.