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Contact allergy from propylene glycol
Author(s) -
Angelini G.,
Meneghini C. L.
Publication year - 1981
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/j.1600-0536.1981.tb04042.x
Subject(s) - contact dermatitis , allergy , contact allergy , medicine , dermatology , patch test , polyvinyl alcohol , allergic contact dermatitis , skin reaction , irritant contact dermatitis , organic chemistry , chemistry , immunology
Propylene glycol (PG) 20% in water was tested in a group of 400 subjects with eczematous contact dermatitis. In six inpatients (1.5%) reactions were recorded as considered positive according to the Following criteria: 1. the relevant history of prolonged contact with PC‐containing topical pharmaceutical and cosmetic preparations; 2. the reaction extended in time outside the area of application of the test substance, and persisted locally for several days; 3. a similar reaction was obtained on repetition of the lest with a lower concentration of PG; 4. the prompt improvement in clinical manifestations of eczema on withdrawal of PG‐containing topical preparations. With the PG concentration employed no irritant reactions were observed.