Premium
Contact sensitivity to quinidine sulfate from occupational exposure
Author(s) -
Wahlberg Jan E.,
Boman Anders
Publication year - 1981
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/j.1600-0536.1981.tb03955.x
Subject(s) - quinidine , quinine , guinea pig , pharmacology , toxicity , chemistry , medicine , immunology , malaria , organic chemistry
Three workers exposed to quinidine sulfate became sensitized after short exposure times (2–3 months). They were patch test positive to quinidine in different vehicles, hut negative to the diastereoisomer quinine. Guinea pig maximization tests demonstrated quinidine and quinine to be grade V allergens according to the classification of Magnusson & Kligman, When challenged for cross reactivity, the animals sensitive to quinine did not react to quinidine. Among the quinidine‐sensitive guinea pigs, three of 20 ( P > 0.05) reacted when challenged with quinine.