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Further studies of effects of vehicles and elicitation concentration in experimental contact sensitization testing in humans
Author(s) -
Marzulli Francis N.,
Mafbach Howard I.
Publication year - 1980
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/j.1600-0536.1980.tb03921.x
Subject(s) - sensitization , allergic contact dermatitis , contact allergy , contact dermatitis , alcohol , skin sensitization , medicine , dermatology , chemistry , toxicology , allergy , immunology , biology , organic chemistry
Further confirmation of the effects of vehicles and elicitation concentration in experimental contact sensitization testing with fragrance ingredients is reported. A dose‐response relation was seen when sensitized human subjects were challenged with dihydrocoumarin, alantroot oil and diethylmalleate. Furthermore, alcohol was shown to be a more effective vehicle than petrolatum, when cinnamon bark oil, vetiver acetate and diethylmalleate were used in predictive tests. The relation of these findings to risk‐benefit judgments is discussed briefly.