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Nickel cobalt and chromium sensitivity in patients with pompholyx (dyshidrotic eczema)
Author(s) -
Vien Niels K.,
Kaaber Knud
Publication year - 1979
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/j.1600-0536.1979.tb04907.x
Subject(s) - patch test , potassium dichromate , cobalt , dermatology , contact dermatitis , chromate conversion coating , medicine , nickel , allergic contact dermatitis , cobalt chloride , patch testing , allergy , hand eczema , contact allergy , ingestion , chromium , metallurgy , chemistry , immunology , materials science , inorganic chemistry
Sixteen patients with negative routine patch tests were challenged orally in a controlled trial with 2.5 mg nickel, I nig cobalt, and 2.5 nig chromium given as salts of the respective metals. All of the patients had symmetrical, vesicular hand dermatitis and in some cases also foot involvement. The dermatitis of two patients flared after challenge with cobalt; in two patients flare occurred following chromate ingestion. Prior to the oral challenge all the patients were patch tested with nickel sulphate, cobalt. chloride and potassium dichromate after adhesive tape stripping. Solutions of the same metal salts were used for intradermal testing. The intradermal test sites were read after 20 minutes and 48 hours, the patch tests, after 4Nh. Skin test reactivity correlated poorly to the results of the oral challenge, possibly due to nonspecific skin test reactivity. It is concluded that oral challenge is it valuable adjunctive diagnostic procedure in patients with pompholyx. Who have negative routine patch tests.