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Photoepicutaneous testing UV‐induced protection against photoxic reactions in normal and vitiliginous skin: A clinical and histological study
Author(s) -
Suhonen Raimo,
Niemi KirstiMaria
Publication year - 1978
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/j.1600-0536.1978.tb03716.x
Subject(s) - phototoxicity , vitiligo , methoxsalen , dermatology , medicine , skin reaction , irradiation , chemistry , psoriasis , biochemistry , physics , nuclear physics , in vitro
The effect of erythemic UV irradiation on the phototoxic reactions caused by topical methoxsalen + UVA exposure was studied on normal skin, normal‐looking skin of vitiligo patients, and vitilginous skin. Although only slight historical changes were delectable 9 days after irradiation with 5 MED of erythemic UV, this pre‐irradiation did induce protection against phototoxic reactions in all skin types. This protection WHS clinically equal in all skin types; the slight differences were not statistically significant. Histological evaluation, however, showed a most conspicuous protective effect on vitiliginous skin. In all skin types the influence of UV pre‐irradiation was confined to epidermal protection; the dermal phototoxic changes were unaffected.